Key Publications


For further information about any of these publications please contact us here.

 

2016

Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma. Vongsuvanh R, van der Poorten D, Iseli T, Strasser SI, McCaughan GW, George J. PLoS One May 24

2016

Antagonizing Midkine Accelerates Fracture Healing in Mice by Enhanced Bone Formation in the Fracture Callus. Haffner-Luntzer M, Heilmann A, Rapp AE, Roessler R, Schinke T, Amling M, Ignatius A, Liedert A. Br J Pharmacol. Apr 25

2016

Midkine Deteriorates Cardiac Remodeling via Epidermal Growth Factor Receptor Signaling in Chronic Kidney Disease. Honda Y, Shishido T, Takahashi T, Watanabe T, Netsu S, Kinoshita D, Narumi T, Kadowaki S, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Kishida S, Kadomatsu K, Takeishi Y, Kubota I. Hypertension.67(5):857-65

2016

Chondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine. Solera C, Macchione G, Maza S, Kayser MM, Corzana F, de Paz JL, Nieto PM. Chemistry 22 2356-69

2016

High expression of Midkine (MK) indicates poor prognosis in childhood acute lymphoblastic leukemia. Jia M, Zhao HZ, Cheng YP, Luo ZB, Zhang JY, Li SS, Xu XJ, Tang YM. Hematology. 21:69-77

2015

Midkine: In the Middle of the Pathogenesis of Acute Respiratory Distress Syndrome-associated Lung Fibrosis? Siempos II, Choi AM. Am J Respir Crit Care Med. 192: 271-2

2015

Mechanical Stress and the Induction of Lung Fibrosis via the Midkine Signaling Pathway. Zhang R, Pan Y, Fanelli V, Wu S, Luo AA, Islam D, Han B, Mao P, Ghazarian M, Zeng W, Spieth PM, Wang D, Khang J, Mo H, Liu X, Uhlig S, Liu M, Laffey J, Slutsky AS, Li Y, Zhang H. Am J Respir Crit Care Med. 192: 315-23

2015

Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain. He D, Chen H, Muramatsu H, Lasek AW. J Neurochem. 135: 508-21

2015

Regulation of Pleiotrophin, Midkine, Receptor Protein Tyrosine Phosphatase β/ζ, and Their Intracellular Signaling Cascades in the Nucleus Accumbens During Opiate Administration. García-Pérez D, Laorden ML, Milanés MV. Int J Neuropsychopharmacol. Jul 11; 19(1)

2015

Midkine and Pleiotrophin in the Treatment of Neurodegenerative Diseases and Drug Addiction. Alguacil LF, Herradón G. Recent Pat CNS Drug Discov. 10: 28-33.

2015

Midkine-a protein localization in the developing and adult retina of the zebrafish and its function during photoreceptor regeneration. Gramage E, D'Cruz T, Taylor S, Thummel R, Hitchcock PF.  PLoS One. Mar 24;10(3)

2015

Midkine: a novel and early biomarker of contrast-induced acute kidney injury in patients undergoing percutaneous coronary interventions. Malyszko J, Bachorzewska-Gajewska H, Koc-Zorawska E, Malyszko JS, Kobus G, Dobrzycki S. Biomed Res Int.;2015:879509.

2014

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. Haffner-Luntzer M, Heilmann A, Rapp AE, Beie S, Schinke T, Amling M, Ignatius A, Liedert A. PLoS One. 9 :e116282.

2014

Pleiotrophin differentially regulates the rewarding and sedative effects of ethanol. Vicente-Rodríguez M, Pérez-García C, Ferrer-Alcón M, Uribarri M, Sánchez-Alonso MG, Ramos MP, Herradón G. J Neurochem. 131:688-95

2014

Jones, D. R. Measuring midkine: the utility of midkine as a biomarker in cancer and other diseases. Br J Pharmacol.

2014

Herter JM, Mayadas TN. Midkine, a middle manager of β2 integrins. Blood, 123, 1777-9.

2014

Fan N, Sun H, Wang Y, Zhang L, Xia Z, Peng L, Hou Y, Shen W, Liu R, Peng Y. Midkine, a Potential Link between Obesity and Insulin Resistance. PLoS One. 9, e88299.

2014

Weckbach LT, Gola A, Winkelmann M, Jakob SM, Groesser L, Borgolte J, Pogoda F, Pick R, Pruenster M, Müller-Höcker J, Deindl E, Sperandio M, Walzog B. The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via β2 integrins (CD11/CD18). Blood.

2013

Hao H, Maeda Y, Fukazawa T, Yamatsuji T, Takaoka M, Bao XH, Matsuoka J, Okui  T, Shimo T, Takigawa N, Tomono Y, Nakajima M, Fink-Baldauf IM, Nelson S, Seibel W, Papoian R, Whitsett JA, Naomoto Y. Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer. PLoS One. 8, e71093.

2013

Liang J, Ding T, Guo ZW, Yu XJ, Hu YZ, Zheng L, Xu J. Expression pattern of tumour-associated antigens in hepatocellular carcinoma: association with immune infiltration and disease progression. Br J Cancer. 109, 1031-9.

2013

Kadomatsu K, Kishida S, Tsubota S. The heparin-binding growth factor midkine: the biological activities and candidate receptors. J Biochem. 153, 511-21.

2013

Barderas R, Mendes M, Torres S, Bartolomé RA, López-Lucendo M, Villar-Vázquez R, Peláez-García A, Fuente E, Bonilla F, Casal JI. In-depth characterization of the secretome of colorectal cancer metastatic cells identifies key proteins in cell adhesion, migration, and invasion. Mol Cell Proteomics. 12, 1602-20.

2013

Lim J, Yao S, Graf M, Winkler C, Yang D. Structure-function analysis of full-length midkine reveals novel residues important for heparin binding and zebrafish embryogenesis. Biochem J. 451, 407-15.

2012

Wellstein A. ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers. Front Oncol. 2, 192.

2012

Shachar I, Cohen S, Marom A, Becker-Herman S. Regulation of CLL survival by hypoxia-inducible factor and its target genes. FEBS Lett. 586, 2906-10.

2012

Weckbach LT, Groesser L, Borgolte J, Pagel JI, Pogoda F, Schymeinsky J, Müller-Höcker J, Shakibaei M, Muramatsu T, Deindl E, Walzog B. Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis. Am J Physiol Heart Circ Physiol. 303, H429-38.

2012

Xu YY, Mao XY, Song YX, Zhao F, Wang ZN, Zhang WX, Xu HM, Jin F. Midkine confers Adriamycin resistance in human gastric cancer cells. Tumour Biol. 33, 1543-8.

2012

Ota T, Jono H, Ota K, Shinriki S, Ueda M, Sueyoshi T, Nakatani K, Hiraishi Y, Wada T, Fujita S, Obayashi K, Shinohara M, Ando Y. Downregulation of midkine induces cisplatin resistance in human oral squamous cell carcinoma. Oncol Rep. 27, 1674-80.

2012

Sonobe Y, Li H, Jin S, Kishida S, Kadomatsu K, Takeuchi H, Mizuno T, Suzumura A. Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells. J Immunol. 188, 2602-11.

2012

Cohen S, Shoshana OY, Zelman-Toister E, Maharshak N, Binsky-Ehrenreich I, Gordin M, Hazan-Halevy I, Herishanu Y, Shvidel L, Haran M, Leng L, Bucala R, Harroch S, Shachar I. The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74. J Immunol. 188, 259-69.

2012

Sueyoshi T, Jono H, Shinriki S, Ota K, Ota T, Tasaki M, Atsuyama E, Yakushiji T, Ueda M, Obayashi K, Mizuta H, Ando Y. Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma. Cancer Lett. 316, 23-30.

2011

Hung YJ, Lin ZH, Cheng TI, Liang CT, Kuo TM, Kao KJ. Serum midkine as a prognostic biomarker for patients with hepatocellular carcinoma. Am J Clin Pathol. 136, 594-603.

2011

Ishiguro H, Horiba M, Takenaka H, Sumida A, Opthof T, Ishiguro YS, Kadomatsu K, Murohara T, Kodama I. A single intracoronary injection of midkine reduces ischemia/reperfusion injury in Swine hearts: a novel therapeutic approach for acute coronary syndrome. Front Physiol. 2, 27.

2011

Güngör C, Zander H, Effenberger KE, Vashist YK, Kalinina T, Izbicki JR, Yekebas E, Bockhorn M. Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer. Cancer Res. 71, 5009-19.

2011

Lorente M, Torres S, Salazar M, Carracedo A, Hernández-Tiedra S, Rodríguez-Fornés F, García-Taboada E, Meléndez B, Mollejo M, Campos-Martín Y, Barcia JA, Guzmán M, Velasco G. Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death. Autophagy. 7, 1071-3.

2011

Lorente M, Torres S, Salazar M, Carracedo A, Hernández-Tiedra S, Rodríguez-Fornés F, García-Taboada E, Meléndez B, Mollejo M, Campos-Martín Y, Lakatosh SA, Barcia J, Guzmán M, Velasco G. Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action. Cell Death Differ. 18, 959-73.

2010

Kadomatsu K. Midkine regulation of the renin-angiotensin system. Curr Hypertens Rep. 12, 74-9.

2010

Kitahara T, Shishido T, Suzuki S, Katoh S, Sasaki T, Ishino M, Nitobe J, Miyamoto T, Miyashita T, Watanabe T, Takeishi Y, Kubota I. Serum midkine as a predictor of cardiac events in patients with chronic heart failure. J Card Fail.  16, 308-13.

2010

Krzystek-Korpacka M, Neubauer K, Matusiewicz M. Circulating midkine in Crohn's disease: clinical implications. Inflamm Bowel Dis. 16, 208-15.

2009

Hobo, A., Yuzawa, Y., Kosugi, T., Kato, N., Asai, N., Sato, W., Maruyama, S., Ito, Y., Kobori, H., Ikematsu, S., Nishiyama, A., Matsuo, S. & Kadomatsu, K. The growth factor midkine regulates the renin-angiotensin system in mice. J Clin Invest, 119, 1616-25.

2009

Takenaka, H., Horiba, M., Ishiguro, H., Sumida, A., Hojo, M., Usui, A., Akita, T., Sakuma, S., Ueda, Y., Kodama, I. & Kadomatsu, K. Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction. Am J Physiol Heart Circ Physiol, 296, H462-9.

2008

Ota K, Fujimori H, Ueda M, Shiniriki S, Kudo M, Jono H, Fukuyoshi Y, Yamamoto Y, Sugiuchi H, Iwase H, Shinohara M, Ando Y. Midkine as a prognostic biomarker in oral squamous cell carcinoma. Br J Cancer. 99, 655-62.

2008

Wang, J., Takeuchi, H., Sonobe, Y., Jin, S., Mizuno, T., Miyakawa, S., Fujiwara, M., Nakamura, Y., Kato, T., Muramatsu, H., Muramatsu, T. & Suzumura, A. Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population. Proc Natl Acad Sci U S A, 105, 3915-20.

2008

Fukui S, Kitagawa-Sakakida S, Kawamata S, Matsumiya G, Kawaguchi N, Matsuura N, Sawa Y. Therapeutic effect of midkine on cardiac remodeling in infarcted rat hearts. Ann Thorac Surg. 85, 562-70.

2007

Wang Q, Huang Y, Ni Y, Wang H, Hou Y. siRNA targeting midkine inhibits gastric cancer cells growth and induces apoptosis involved caspase-3,8,9 activation and mitochondrial depolarization. J Biomed Sci. 14, 783-95.

2007

Kosugi, T., Yuzawa, Y., Sato, W., Arata-Kawai, H., Suzuki, N., Kato, N., Matsuo, S. & Kadomatsu, K. Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy. Lab Invest, 87, 903-13.