Key Patents



Application No.

Filing Date

Title

Jurisdictions

Key Claims

Granted

Pending

PCT/JP2007/001238

13 Nov 2007

Antibody recognising C-domain of midkine

AU

EP 

JP US

- An antibody (or fragment thereof) which recognises a portion of an epitope located at amino acid residues 62-104 of MK 

- Specific antibody CDR sequences (or fragments thereof) to claimed epitopes

- A pharmaceutical composition for an antibody/fragment to prevent or treat cancer, autoimmune diseases, inflammatory diseases or MS, or other diseases caused by inflammatory cell migration

PCT/AU2012/000251

13 Mar 2012

Antibody recognising N-domain of midkine

WO

- An antibody (or fragment thereof) which recognises a portion of an epitope located at amino acid residues 1-61 of MK 

- Specific antibody CDR sequences (or fragments thereof) to claimed epitopes

- A pharmaceutical composition for an antibody/fragment to prevent or treat cancer, autoimmune diseases, inflammatory diseases or MS, surgical adhesions, or other diseases caused by inflammatory cell migration

PCT/JP00/06147

08 Sep 2000

Early cancer tumor marker

AU CA CN EP KR US

 

- A method of screening for early cancer by measuring MK, or a fragment of MK, in patient blood or urine

- A method to assess cancer prognosis

PCT/JP2006/322659

14 Nov 2006

Method for treatment or prevention of disease associated with functional disorder of regulatory 
T cell

JP US

 

 EU

- A proliferative agent for Treg cells comprising a MK inhibitor [anti-MK antibodies, antisense RNA, dsRNA] as an active ingredient 

- A therapeutic or preventative agent for diseases associated with the functional disorder of Tregs

- A method to proliferate Treg cells

- A method to screen Treg drugs

- A method to diagnose Treg disorders by measuring MK expression levels

PCT/JP2004/002888

05 Mar 2004

Preventive for adhesion following abdominal surgery

JP US

EP

- A method of preventing post-laparotomy adhesions by administering to said subject a compound which suppresses midkine protein function

- midkine-binding antibodies or antigen-binding fragment thereof that prevent post-laparotomy adhesions.

PCT/JP98/04299

25 Sep 1998

Preventives or remedies for ischemic diseases

AU CA CH DE FR GB JP KR US

- Drugs for treating or preventing cell injury caused by ischemia which contain as the active ingredient midkine family proteins

- Drugs for treating or preventing ischemic diseases which contain as the active ingredient midkine family proteins

PCT/JP2005/022354

06 Dec 2005

Composition for treating or preventing myocardial disorder or heart failure

DE FR JP 

US

- A pharmaceutical composition for treating or preventing myocardial damage and heart failure with MK as an active ingredient 

- A method for preventing or treating myocardial damage and heart failure by administration of MK

PCT/JP99/04550

24 Aug 1999

Pharmaceutical compositions for the prevention and treatment of atherosclerosis and restenosis after PTCA

AU CA CN EP JP KR US

US

- A pharmaceutical composition for preventing or treating angiostenosis comprising an inhibitor of MK [antisense RNA, anti-MK antibodies] as an active ingredient

- A method of preventing or treating angiostenosis using a MK inhibitor

PCT/JP2006/310375

25 May 2006

Pharmaceutical composition for vascular occlusive disease

CH DE ES FR GB IT   

- A pharmaceutical composition for obstructive vascular disease comprising an anti-MK siRNA plus a collagen molecule

- Specific anti-MK siRNA sequences

- A medical device [stent] with anti-MK siRNA incorporated

PCT/JP98/003161

14 Jul 1998

Agents comprising midkine or its inhibitors as active ingredient

AU CA CN EP KR US

JP

- A method for inhibiting neutrophilic function using a MK inhibitor, including anti-MK antibodies

- A method for treating an inflammatory disease in which MK levels are elevated

US 6,867,037

10 Aug 1999

High level secretory expression system of intact MK family protein

US

 

- A vector for secretory expression of an intact MK family protein by a methylotrophic yeast

- A method for producing an intact MK family protein in a methylotrophic yeast